Dueling Ca2+ Sensors in Neurotransmitter Release

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Dueling Ca2+ Sensors in Neurotransmitter Release

Ca(2+)-triggered neurotransmitter release is characterized by two kinetically distinct components: a fast synchronous phase and a slow asynchronous phase. Yao et al. (2011) now report that double C2 domain (Doc2) proteins function as high-affinity Ca(2+) sensors to specifically regulate the asynchronous component of neurotransmitter release.

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Synaptic transmission involves a fast synchronous phase and a slower asynchronous phase of neurotransmitter release that are regulated by distinct Ca(2+) sensors. Though the Ca(2+) sensor for rapid exocytosis, synaptotagmin I, has been studied in depth, the sensor for asynchronous release remains unknown. In a screen for neuronal Ca(2+) sensors that respond to changes in [Ca(2+)] with markedly ...

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ژورنال

عنوان ژورنال: Cell

سال: 2011

ISSN: 0092-8674

DOI: 10.1016/j.cell.2011.10.007